Ensembl Macaque

 

Karyotype

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About the Rhesus macaque genome

Assembly

Rhesus macaque Mmul_1 is a preliminary assembly of the rhesus monkey, Macaca mulatta using whole genome shotgun (WGS) reads from small and medium insert clones. Several WGS libraries, with inserts of 2-4 kb and 10 kb, fosmids with ~35kb inserts, and BACs with 180kb inserts were used to produce the data.

The release was produced by the Macaque Genome Sequencing Consortium, led by the Baylor College of Human Medicine, melding three separate complementary assemblies (created using the Atlas, Celera and PCAP systems). This involved iteratively splitting likely chimeric scaffolds and joining together existing scaffolds where possible. Chimeric scaffolds (<100 total) were identified by breaks in synteny with the human genome, which were confirmed to be artefacts by the other assemblies.

This is a draft sequence and may contain errors so users should exercise caution. Typical errors in draft genome sequences include misassemblies of repeated sequences, collapses of repeated regions, and unmerged overlaps (e.g. due to polymorphisms) creating artificial duplications. However base accuracy in contigs (contiguous blocks of sequence) is usually very high with most errors near the ends of contigs. [More about the assembly].

Annotation

The gene set for macaque was built using the ensembl pipeline. The species-specific resources for macaque are relatively limited, so we decided to take a combined approach utilizing macaque's great similarity to human to aid our annotation efforts. The gene structures are mainly based on alignments to human and macaque protein data. Both macaque and human cDNAs were used to add UTR structures, and finally gene predictions based on Uniprot proteins and human cdnas were used to fill gaps in the annotation.

What's New in Ensembl 41

Macaca mulatta News

  • Compara - whole genome alignments and syntenies

    Whole Genome Alignments

    Chimp (Pan troglodytes)
    Owing to the new Chimp assembly and genebuild, there is a new MLAGAN primate 3-way alignment of human, chimp and macaque.
    Read more...
  • RNA updates

    Ensembl RNA data has been updated as follows:

    • New ncRNAs for Zebrafish, Chimp, Medaka, Elephant, Rabbit, Armadillo and Tenrec
    • Updated miRNAs for all chordates.

General News

  • New animated tutorials
    A selection of Ensembl tutorials are now available online as Flash-animated presentations (with popup notes instead of a soundtrack).
    Read more...
  • Compara updates
    Homologies
    Gene trees have been updated to include the 2X genomes and use a multifurcating species tree, and homologues added based on gene trees.
    Read more...
  • Minor schema changes
    analysis_description
    Now has a 'displayable' flag to control whether or not it is usually displayed in the web pages
    xref
    One column has been changed and one added
    • the info_type column has addition ENUM values to give more details about xref provenance
    • A new column 'priority' supports the fetching of xrefs of the same type

    The API has of course been updated to reflect these changes

    .
    Read more...

More news...

Statistics

Assembly: MMUL 1.0, Feb 2006
Genebuild: Ensembl, Jan 2006
Database version: 41.10a
Known genes: 874
Projected genes: 16,332
Novel genes: 4,839
Pseudogenes: 1,762
RNA genes: 3,622
Genscan gene predictions: 125,893
Gene exons: 247,383
Gene transcripts: 38,308
Base Pairs*: 3,093,871,206
Golden Path Length**: 3,097,179,960
Most common InterPro domains: Top 40 Top 500

* Total number of base pairs = sum of lengths of DNA table

** Reference assembly (Golden path) length = sum of non-redundant top level seq regions


 

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Ensembl release 41 - Oct 2006
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